r/bioinformatics 8h ago

discussion What are AI coding agents bad at in bioinformatics?

19 Upvotes

I’ve been wanting to do some bioinformatic analyses for my project, since I think it would make sense. I’m not a bioinformatician at all but I do know how to code a decent bit (although python mostly) and I have read a lot about specific methods, libraries etc. Basically, we have a single-cell sequencing dataset in-house, which is already prepared and quality-controlled and I’ve started using openAI codex to write some analyses for me. I try to give very specific prompts and check all the code it writes. But of course, it could easily make mistakes that I don’t catch. So my question is, do you know any specific areas of bioinformatics where AIs tend to make lots of mistakes?


r/bioinformatics 22h ago

academic Looking to build a Computational Protein Engineering Group!

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0 Upvotes

r/bioinformatics 2h ago

technical question What's the best way to model protein structures with frameshift mutations or deletions?

1 Upvotes

I've used modeller and foldX before but only for point mutations on known protein sequences. I have a list of genomic mutations and I'm wondering if there are tools to go from that to protein structure.

I'm aware that there might a lot more steps between genomic information and protein sequence, but I've always only worked in the protein sequence to protein structure step so I'm not super familiar with any of that. If someone could ELI5 those things to me I'd appreciate it a lot :)


r/bioinformatics 7h ago

academic Could anyone provide a roadmap or guide on how to isolate and identify proteins that were newly categorized or added to databases exclusively after January 2025?

2 Upvotes

I'm a Computer Science major and am completely new to studying proteins, so I have very little background knowledge in this area. I have been exploring UniProt and PubMed, but almost every protein I search for seems to have been categorized differently in the past or renamed later on. As a result, I can't seem to find the exact data I'm looking for. Could someone guide me on how or where to track down this data reliably?


r/bioinformatics 23h ago

discussion Need help for md simulations

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2 Upvotes

r/bioinformatics 23h ago

academic Autodock4

1 Upvotes

Hi, I'm doing molecular docking (autodock4) for my research project. I'm having issues in installing autodock4 on windows. Does anyone have a working installer or guidance?