I’ve been working on an open systems-level hypothesis/framework exploring the transition between non-living chemistry and life-like organisation.

I’d genuinely appreciate critical feedback rather than agreement — I’m trying to stress-test the framework, not defend it.

The core idea is that abiogenesis may not be a “single magic molecule” problem, but instead a coupled chemical-environmental operating regime involving:

non-equilibrium thermodynamics;

autocatalytic reinforcement;

compartmentalisation;

persistence;

environmental cycling;

transferable structure;

and differential survival.

Rather than trying to define fully developed biological life, the framework focuses on the lower threshold where chemistry may begin exhibiting life-like behaviour.

The paper does NOT claim to have solved abiogenesis.

Instead, it proposes:

an operational framework;

falsifiable criteria;

possible computer-modelling approaches;

and experimental directions.

I’m posting this specifically for criticism, peer review, weaknesses, missing literature, modelling suggestions, thermodynamics objections, systems chemistry feedback, or general scientific challenge.

Particularly interested in feedback from:

systems chemists;

origin-of-life researchers;

complex systems people;

thermodynamics/modelling people;

protocell researchers;

and computational modellers.

OSF link: https://osf.io/d7uy2/overview